A STUDY ON THE EXPRESSION PATTERNS OF ER, PGR, HER2/NEU AND ITS HISTOMORPHOLOGY IN BREAST CARCINOMA
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 2085-2100
AbstractBackground: To study breast carcinoma based on the expression patterns of ER, PgR, HER2/neu and its Histomorphology.
Materials and Methods: The present study is a 4 years study, 1 year retrospective and 3 year prospective study from 1st November 2017 to 31st October 2021, done in the Department of Pathology Kamineni Institute of Medical Sciences, Narketpally. Specimens received with a clinical diagnosis of carcinoma of breast were processed according to standard protocol. The specimen received following neoadjuvant chemotherapy was excluded from the study. Histomorphology of tumor, Nottinghams modification of Scarff Bloom Richardson grading was studied by H&E stained section and the ER, PgR and HER2/neu expression studied by IHC stains.
Results: A total of 86 cases of breast carcinomas were analysed. Most of the cases occurred in perimenopausal age group. Lump in the breast was the most common presenting symptom. Majority of tumor were within the size of >2-5cm, frequently in upper outer quadrant. Invasive breast carcinoma no special type was most common type, accounting to 81.40%, followed by invasive lobular carcinoma of breast in 5.81%. Majority of tumor were of Grade II. ER, PgR and HER2/neu were expressed in 53.48%, 43.03% and 39.54% of cases. The most common molecular subtype was ER /PgR+/HER2neu. Hormonal receptor expression was less in women with age above 40 years, with increase in size and grade of tumor and with increase in number of metastatic lymphnode. Expression of HER2/neu increased with increase in grade of tumor. HER2/neu expression decrease in women more than 40 years. No relation was observed between HER2/neu expression and number of metastatic lymph nodes.
Conclusion: As the scenario of breast carcinoma in India is changing, the knowledge regarding histological parameters like type, grading and staging along with hormone receptor expression and HER2/neu amplification are important as it will guide the clinician to choose the most appropriate modality of treatment for the best possible outcome in a patient with breast carcinoma.
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