TO ESTIMATE LEVEL OF ZINC AND FRUCTOSE IN NORMOSPERMIC AND OLIGOSPERMIC MALES
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 2138-2148
AbstractINTRODUCTION: Infertility has often been defined as failure to achieve pregnancy within one year of unprotected intercourse. Seminal plasma is very important for sperm metabolism, function, survival, and transport in the female genital tract.Zinc deﬁciency may lead to gonadal dysfunction, decrease in testicular weight and shrinkage of seminiferous tubules. Zinc may have a role in sperm production, viability and in the prevention of spermatozoa degradation.Fructose concentration is considered a good measure to evaluate seminal vesicular function and has been studied in great detail, and its concentration can depend on number of factors such as time since collection and the age of the donor.
MATERIAL AND METHODS: This is a cross-sectional study.Semen examination of the patients visiting the gynecology department of the Government Medical College, Aurangabad was carried out according to the standardized method of the World Health Organization from January 2016 to January 2017. A complete medical history of the patients was recorded. The collection and analysis of semen were done by properly standardized procedures as mentioned in WHO Laboratory Manual (2010). Males with primary and secondary infertility without treatment, of the ages between 20-45 years males.
RESULTS: The mean of sperm count in oligospermic subjects is 10.84 ± 7.118 millions/ml of semen ranging 1-15 million/ml which is significantly lower than that of the normospermic subjects i.e; 92.88 ± 79.93 millions/ml, within a range of 32 – 170 million/ml (p < 0.001). In addition, the mean sperm motility in oligospermic men is 40.56 ± 53.82%, ranged within 0-100% is significantly lower than that of the control group 65.6 ± 41.50 %, which ranged from 30 - 98 % (p < 0.001). The mean of seminal plasma zinc in oligospermic men is1.65 ± 0.936μmol/ejaculate, ranged within 0.2- 2.9μmol/ejaculate is significantly lower than that of the control group4.074 ±1.199μmol/ejaculate which ranged from 2.66 – 4.9μmol/ejaculate (p < 0.001).
CONCLUSION: From our study we can conclude that biochemical parameters that is zinc and fructose level in seminal plasma have direct effect on physical parameters like sperm count and motility that‟s why we should incorporate these parameters in routine semen analysis. Also as dietary zinc affects seminal zinc level, zinc should be supplemented and dietary zinc should be adequate.
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