EVALUATION OF EFFECT OF RADIOTHERAPY ON RESPONSE OF CERVICAL CANCER PATIENTS: A MULTI INSTITUTIONAL STUDY
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 12094-12099
AbstractBackground: Cervical cancer is among the most frequent cancer types in women worldwide. Radiotherapy, including external beam radiation and brachytherapy, is one of the commonly used treatment options for cervical cancer. However, the response and adverse effects of radiation therapy on cervical cancer survival have been poorly investigated with inconclusive result. Therefore, the aim of this study was possibly to explore the potential factors that might affect the response to radiotherapy in patients affected with cervical cancer and thus providing information for an eminent decision making in a way to a better therapy.
Materials and Methodology: This study included 150 cases for the effective analysis. The data of the all the subject analysed were diagnosed with cervical cancer based on histopathology examination where a complete standard-protocol radiotherapy [external curative dose of 46–50 Gy (25 fractions) using Photon on LINAC with 6-10 Mega Volt energy, continued to brachytherapy using the after loading method HDR microselectron unit of 129Ir, dose 700cGy, three times to A-point week apart].
Results: Of the total of 150 cases, 102 cases (68.29%) showed a complete response, 37 cases (24.39%) developed a partial response, seven cases (4.88%) had a stable response, and four cases (2.44%) were progressive. There were no observed gastrointestinal side effects (grade 0) for 121 cases (80.49%), 24 cases were grade 1 (16.26%), five cases were from grade 2 (3.25%), and no cases were seen grade 3.
Conclusion: Most of definitive-curative radiotherapy responses for patients with stage IIA-IIIB cervical cancer were complete (68.29%). Partial response was seen in 24.49%, stable response in 4.88% and progressive response in 2.44%. The clinical characteristics that are significantly associated with the complete response to radiotherapy was seen in the largest tumour diameter. Clinicopathological factors like age, BMI, blood haemoglobin level, blood leucocyte count, serum albumin level, FIGO stage, histopathology and tissue differentiation were not statistically significant.
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