Abstract

Introduction: Osteosarcoma (OS) is the relatively most prevalent bone malignancy accounting for 20% of primary bone tumors. Differential diagnosis of OS is a daunting problem as they can masquerade with different kinds of bone tumors. None of the studies correlate the radiological findings of suspected cases of osteosarcoma with biopsy.
Purpose: The purpose of this retrospective study is to correlate the radiological findings with biopsy of suspected osteosarcoma.
Materials and Methods: The current retrospective study was carried out in the Department of Orthopaedics in collaboration of Department of Pathology at a tertiary care center in north India from 2015 to 2021. A total of 162 patients of suspected OS included in this study after carefully examination of clinical and radiological features analyzed by two Orthopaedic surgeons. The differential diagnosis of OS was observed in all patients through analyzing the clinical and radiological features followed by biopsy. The accuracy of radiology was calculated against biopsy procedure. 
Results: Out of 162 patients, 102 patients were male and 60 were female with a mean age of 29.65±10.55 years. The accuracy of clinical and radiological findings as compared to biopsy diagnostic procedures was 44.44%. A discrepancy between radiology and biopsy was 55.56%.
Conclusion: Radiological finding reveals that OS mimics different kinds of tumors reflected with low diagnostic accuracy of radiology. Hence, biopsy must consider confirming the diagnosis of bone tumors.