PITAVASTATIN AND GEMFIBROZIL AS DRUG REPOSITIONING CANDIDATES FOR ANXIOLYTIC ACTIVITY: AN ANIMAL STUDY BY USING ELEVATED PLUS MAZE
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 2563-2574
Abstract
Anxiety is a common finding in most neurotic disorders and plays a remarkable role in their pathogenesis. [1] Before the 20th century, “anxiety neurosis” and “pantophobia” terms were used to diagnose general anxiety. [2] In most anxiety cases, a person feels worsened episodes of symptoms followed by symptom-free episodes. This condition is referred to as “remitting and relapsing conditions.” [3] The exact cause of anxiety is still a topic of discussion; it may be due to inflection in the central nervous system. [4] Dyslipidemia is a solid soothsayer of persistent medical conditions like obesity that could elevate the risk of anxiety. [5] Several pathways, such as neurotransmitter balance, oxidative stress, and immuno-inflammatory processes associated with anxiety, are also connected with obesity
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