A PROSPECTIVE STUDY OF ENDOMETRIUM IN LEIOMYOMA UTERUS
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 2656-2662
AbstractBackground: Leiomyoma (fibroid) is the commonest neoplasm accounting for 75% of benign tumours affecting women in reproductive age group. They are dependent upon the steroid hormones for their growth and maintenance. As the endometrium and leiomyoma (fibroid), are both steroid hormone dependent, we studied the corresponding histological changes in endometrium in cases of uterine leiomyoma.
Materials and Methods: The study included 100 hysterectomy cases where leiomyoma/leiomyomas were present. Brief clinical history regarding age, clinical presentation, parity was obtained. The specimens were fixed in 10% formalin; tissue bits from representative areas were taken and stained with Haematoxylin and Eosin.
Results: The commonest age group was 4th decade (54%). The commonest clinical presentation or chief complaint in current study is menorrhagia (46% cases). Majority of the women in the study were multiparous (89%) and the most common type of leiomyoma encountered in the study, based on location, was intramural type (62% cases). Proliferative pattern of endometrium (62%) is the most common pattern associated with leiomyomatous uteri in this study.
Conclusion: Uterine fibroids (leiomyomas) are the most common benign gynecological tumors in women of reproductive age globally. Endometrium and leiomyoma (fibroid), are both dependent on steroid hormones for the growth and maintenance. Histopathological diagnosis is the mainstay to identify the uterine leiomyoma, though some amount of clue may be obtained from the endometrial curettings.
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