European Journal of Molecular & Clinical Medicine

Abstract

Background: Chronic airway inflammation is a hallmark of asthma, but the usefulness of high-sensitivity C-reactive protein tests (hs-CRP), which are known to be sensitive markers of low-grade systemic inflammation, has not been thoroughly investigated in asthma. Estimation of blood hs-CRP levels in asthma patients and their correlation with clinical traits and levels of airway inflammation are the objectives of this study.
Methods: Based on the inclusion and exclusion criteria n=40 cases were included in the study. The demographic profile data was collected using a pretested and structured questionnaire. A detailed history of asthma was obtained along with a complete clinical examination of the patient. The investigations included Pulmonary function tests, Complete blood count, estimation of serum hs-CRP, IgE levels, and Absolute eosinophil count.
Results: The atopic asthma group had the mean value of serum IgE 924.53 ± 205.63 IU/ml compared to the mean value of 198.17± 59.36 IU/ml. The difference was found to be statistically significant. The comparison between mild intermittent and mild persistent cases showed p values were 0.0141 hence it was significant. Comparison between mild persistent and moderate persistent showed p values 0.236 hence insignificant. The intergroup comparison between three groups with ANOVA showed p values of 0.0136 hence it was considered significant
Conclusion: In the current studyit was found that there is a possibility to use hs-CRP as a marker of ongoing inflammatory activity as well as the effectiveness of treatment because patients with recent asthma attacks have elevated hs-CRP levels. The absolute eosinophil counts are much greater in the allergic asthma group, and the levels of AEC are correlated with illness severity.