HISTOPATHOLOGICAL STUDY OF VESICULOBULLOUS SKIN LESIONS– A PROSPECTIVE STUDY IN A TERTIARY CARE HOSPITAL
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 2855-2861
Abstract
Background: Skin is the largest organ of the body and various diseases can commonly involve the skin out of which vesiculobullous lesions form one of predominant group. Histopathological study of bullous skin lesions andto knows the incidence of bullous lesions and to study bullous lesions in relation to age and sex.Materials and Methods: A prospective study of vesiculobullous disorders were studied over aspan of 24 months from July 2019 to June 2021. A total of 48 skin biopsies from patients with vesiculobullous skin lesions were sent to the Department of Pathology, Guntur Medical College, Guntur. Punch biopsies were taken for histopathological diagnosis. H& E staining was done.
Results: In the present study pemphigus foliaceus is the most common vesiculobullous disorder (35.41%) followed by pemphigus vulgaris in 18.75% of cases. Majority of patients presented between 31-40yrs of age with female prepondarance. Subcorneal blister was noted in pemphigus foliaceus and suprabasal blister was seen in pemphius vulgaris.Dermoepidermal junction separation was seen in bullous pemphigoid, dermatitis herpitiformis, and bullous SLE.
Conclusion: Vesiculobullous disorders represent a heterogeneous group of dermatoses with female preponderance and peak incidence inthird decade. Pemphigus foliaceus constituted the most common subtype of vesiculobullous disorder in this study followed by Pemphigus vulgaris.
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