Thyroid Dysfunction in Patients with Liver Cirrhosis and its Association with the Severity of Liver Disease: A Cross-sectional Study
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 3302-3307
AbstractIntroduction: The majority of cirrhotic liver patients exhibit thyroid problems. The leading global cause of illness and mortality is liver cirrhosis. The metabolism of thyroid hormones is critically impacted by cirrhosis, and via creating thyroid binding globulin, which increases thyroid hormone circulation. Thus, it is evident indicates the severity of liver disease is correlated with thyroid problems. We wanted to investigate how people with thyroid problems' levels of thyroid hormones changed.
Materials and methods In this cross-sectional study, 85 patients who were admitted to tertiary care hospital for symptoms of cirrhosis of liver were evaluated for their thyroid profile along with
other relevant investigations.
Results: There were 15 Female and 70 Male. In individuals with liver cirrhosis, the study found low mean levels of total T4 and free T3, which were substantially linked with Child Pugh grades of liver impairment. There was a correlation between free T3 level and Child Pugh score class. The TSH, total T3, and free T4 mean levels across the Child Pugh classes did not differ in a statistically significant way.
Conclusions: Patients with cirrhosis commonly have thyroid problems. The most frequent problem found was hypothyroidism. Patients with high TSH levels also have a greater rate of problems. Finding thyroid anomalies in cirrhotic patients calls for a healthy dose of caution.
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