European Journal of Molecular & Clinical Medicine

Abstract

Background and objectives: Predicting preeclampsia (PE) at 11-14 weeks of gestation is a new concept. Studies integrating multiple factors at 11-14 weeks of pregnancy have been conducted, but an algorithm with a good predictive value has yet to be created. This study aimed to design a methodology combining MAP, Uterine artery Doppler, and PAPPA at 11-14 weeks of pregnancy to predict PE in India. Basically objective is to determine whether higher Mean Arterial Pressure (MAP), increased Uterine Artery Pulsatility Index (UAPI), and low Pregnancy Associated Plasma Protein A (PAPP - A) between weeks 11-14 of pregnancy are linked to the growth of hypertensive diseases in pregnancy.
Method: This is a prospective cohort study. Data were obtained from 200 registered patients attending antenatal OPD in hospitals between 11 and 14 weeks of gestation. MAP, blood pressure, uterine artery Doppler, and serum sample for PAPPA were measured. IBM SPSS Version 22 for Windows was used to analyse the data.
Result: There were a total of 200 women enrolled in the study, and 24 of those women (37.1%) suffered difficulties. At 11-14 weeks of pregnancy, the uterine artery doppler pulsatality index (PI) was found to be an effective screening tool (sensitivity 29%, specificity 90%) for the prediction of pregnancy.
Conclusion: This study revealed that the uterine artery Doppler Pulsatality index is an effective screening approach for women at high risk of developing preeclampsia and related complications during the 11th to 14th week of pregnancy.