European Journal of Molecular & Clinical Medicine

Abstract

Background: Diabetic patients have an increased risk of developing micro- vascular and macro vascular disease, and platelets may be involved as a causative agent with respect to altered platelet morphology and function. Aim of our study was to determine if platelets were activated in diabetes and to see if there was a difference in MPV in diabetics and non-diabetics.
Methodology: A cross sectional study had been conducted to study the impact of HBA1C on mean platelet volume in Type 2 diabetic patientsand to find out association of mean platelet volume and development of microvascular complication (neuropathy, nephropathy andretinopathy) in diabetics in western Rajasthanattending the Medicine Outdoor and indoor at M.D.M. Hospital Jodhpur.
Conclusion: Platelets in Diabetes Mellitus become more reactive and agreeable and their Mean Platelet Volume (MPV) is increased. Increase in HbA1c concentration is directly proportional to increased MPV, thus poor glycemic control causes increase in MPV which result in more chance of developing microvascular complication. However, the increased MPV as the cause or the end result of microvascular complications needs to be further explored. Hence, we propose that MPV can be used as simple and cost effective tool to monitor the progression and control of Diabetes Mellitus and its associated microvascular complications.