European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Diabetes Mellitus (DM) has been progressively growing in prevalence over time, with overall annualised incidence rates per 1000 people rising from 3.0 in the 1970s to 5.5 in the first decade of the 2000s. This alteration resulted in an 83.3 percent rise in the incidence of T2DM, which was higher among males when compared with females.
Materials and Methods: This a prospective observational study undertaken at a rural tertiary care setting where two patient cohorts are made, one with diabetic patients and other with non-diabetic age and gender matched individuals. The study population (Cohort A) consisted of patients with type 2 diabetes attending the Medicine and Cardiology departments from January 2019 to February 2020. The Cohort B included age and gender matched non-diabetic individuals who are the relatives and attending staff of the patients and the working staff of the hospital.
Results and Discussion: HbA1c levels of 6.5 percent or higher in diabetics were linked to an elevated risk of cardiovascular disease. Glycosylation of haemoglobin may also affect RBC membrane lipid protein interactions, increasing internal viscosity, altering the viscoelastic properties of erythrocyte membranes and lowering RBC deformability.
Conclusion: HbA1c may be a valid predictor of cardiovascular mortality and morbidity in diabetics. The data of our study suggest that the healthcare professionals must appraise the values of HbA1c in assessing the cardiovascular risks and outcomes in the diabetes patients.