European Journal of Molecular & Clinical Medicine

Abstract

Background and Objectives: The aim of this study is the association between uric acid levels and metabolic syndrome in individuals undergoing general health screening. Serum uric acid levels have been reported to be associated with a variety of cardiovascular conditions. Previous epidemiological studies have suggested that hyperuricemia may be a risk factor for cardiovascular diseases. However, on the other hand, many studies argue that the observed association between uric acid and atherosclerosis is attributable to an indirect association of hyperuricemia with cardiovascular risk factor or clustering of these metabolic and hemodynamic risk factors, designated “metabolic syndrome”.
Materials and Methods: The study comprised of metabolic syndrome cases visiting the general medicine outpatient at Government General Hospital, Guntur. Age and sex matched healthy volunteers served as controls. Total 100 out of which 50 cases and 50 controls. Physical Parameters like Waist Circumference (WC), Blood Pressure, Systolic (SBP) & Diastolic (DBP) and Biochemical parameters like Fasting Plasma Glucose (FPG) and Lipid profile Total Triglycerides (TTG), Total Cholesterol (TCH), HDL Cholesterol (HDL-C). Metabolic syndrome is diagnosed using the diagnostic criteria provided by the International Diabetes Federation.
Results: The total numbers of study participants were 100. Out of them 50 cases of central obesity were selected with increased waist circumference and 50 age and sex matched controls were selected with normal waist circumference. Out of 50 obese individuals metabolic syndrome was detected in 23 (46%) of subjects, in 14 (60.86%) of men and in 9 (39.1%) of women and hyperuricemia was detected in 21 (42%) of individuals. The overall serum uric acid (SUA) analysis in the 50 obese group, 21 (Twenty one) are with increased SUA levels. The mean± standard deviation values of all physical (waist circumference, blood pressure) and biochemical parameters (FPG, lipid profile, SUA) of obese group when compared to controls were statistically highly significant.
Discussion: In the present study risk analysis was done among the obese group (waist circumference >90cms in men and >80cms in women) and control group who were non obese. The difference between all the variables (physical and biochemical) of both groups based on the standard error of difference was statistically significant and also the p value (<0.001) that was obtained from Student t test was statistically significant.
Conclusion: in the present study, an elevated serum uric acid concentration was found to be correlated with hypertension, insulin resistance and the risk factors of metabolic syndrome.