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  2. Volume 9, Issue 6
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Online ISSN: 2515-8260

Volume9, Issue6

Comparison of serum magnesium levels and sequential organ failure assessment score in patients with systemic inflammatory response syndrome

    Pranav Ravi Kulkarni, Ashok Raja, Ramkumar Murali, Jagadeesan Mohanan*, Prasanna Karthik Suthakaran, Kannan Rajendran, Mageshkumar Sivanesan, Damodharan Jayachandran

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 802-809

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Abstract

BACKGROUND
Systemic Inflammatory Response Syndrome (SIRS) is an inflammatory condition which affects multiple systems in the body and often occurs as a response which is immunologically mediated by the protective immune system to infectious agent. Magnesium plays a vital role in sepsis and systemic inflammatory response syndrome (SIRS) The aim of this study is to estimate the serum magnesium concentrations in patients with SIRS in the medical ICU, to correlate with prognosis of SIRS patients by comparision with sequential organ failure assessment scoring and to assess the clinical outcome.
 
MATERIALS AND METHODS
This Observational analytical study was conducted in 100 patients admitted at the medical intensive care unit of Saveetha medical college and hospital, chennai who satisfy the diagnostic clinical criteria for SIRS. Detailed clinical examination was done for each patient. Serum magnesium levels were sent and the results were analysed.
 
RESULTS
In the study, 100 patients were included. The mean age of the study population was 42. 92 + 16. 69 years. 70 % of the patients in the study group were  male and 30 % were females. The mortality rate in the hypomagnesemia group was 81. 8% where as it was 14.3 % in the  normomagnesemia  group.  There was Significant mortality in the hypomagnesemia group when compared to the normomagnesemia group. The mean duration of ICU stay for patients in the hypomagnesemia group was 5. 424 days and in the  normomagnesemia group  it  was  5.286  days.  Among 66 patients with hypomagnesemia 50 patients required mechanical ventilation and it was 66 %. Among 28 patients in normomagnesemia group, 2 patients required ventilatory support.
 
CONCLUSION
Serum magnesium levels have prognostic value in  patients diagnosed as SIRS. Serum magnesium concentration shows association with increased mortality rate. There is significant greater need for mechanical ventilation and increased duration of stay under ventilator support in the patients with lower magnesium levels. There is a significant association in prognosticating the patients with SOFA scoring in hypomagnesemia and  magnesium correction may improve the outcomes in sepsis and SIRS patients.
Keywords:
    SIRS SOFA Score Serum magnesium Mortality mechanical ventilation hypomagnesemia normomagnesemia
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(2022). Comparison of serum magnesium levels and sequential organ failure assessment score in patients with systemic inflammatory response syndrome. European Journal of Molecular & Clinical Medicine, 9(6), 802-809.
Pranav Ravi Kulkarni, Ashok Raja, Ramkumar Murali, Jagadeesan Mohanan*, Prasanna Karthik Suthakaran, Kannan Rajendran, Mageshkumar Sivanesan, Damodharan Jayachandran. "Comparison of serum magnesium levels and sequential organ failure assessment score in patients with systemic inflammatory response syndrome". European Journal of Molecular & Clinical Medicine, 9, 6, 2022, 802-809.
(2022). 'Comparison of serum magnesium levels and sequential organ failure assessment score in patients with systemic inflammatory response syndrome', European Journal of Molecular & Clinical Medicine, 9(6), pp. 802-809.
Comparison of serum magnesium levels and sequential organ failure assessment score in patients with systemic inflammatory response syndrome. European Journal of Molecular & Clinical Medicine, 2022; 9(6): 802-809.
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