Document Type : Research Article
Background: Hypertension is an increasing important medical and public health issue. Uric acid exerts a pro-inflammatory effect on endothelial cells which may be associated with MetS risk factors such as elevated triglyceride (TG) levels, hypertension and insulin resistance.5 Present study was aimed to study of association of serum uric acid and blood pressure in hypertensive patients at a tertiary hospital.
Material and Methods: Present study was prospective, comparative, observational study, conducted among cases (Subjects of either gender, age >18 years, diagnosed as hypertensive (first time) were enrolled in this study during a regular routine health check-up at general medicine OPDs) & controls (Age & gender matched normotensives subjects at general medicine OPDs).
Results: In present study, 100 subjects each were studied in hypertensive as well as normotensive group. Mean levels of age, gender, BMI & co-morbidities among both groups were comparable & difference was not significant statistically. Mean pulse rate & respiratory rate were comparable among both groups & difference was not significant statistically. The mean levels of SBP and DBP were significantly more in the hypertensive subjects as compared to normotensive subjects (p<0.001). In present study, prevalence of hyperuricemia was 9% (1% in normotensive and 8% in hypertensive subjects). Hypertensive subjects had increased mean levels of SUA than in the normotensive subjects (p<0.001). In Pearson’s correlation coefficient test, SUA levels were significantly related with SBP and DBP (p<0.001). The average level of TG and HDL were also significantly different between the groups (p<0.05).
Conclusion: A stronger co-relationship for higher levels of SUA concentration was noted with blood pressure hypertension and prehypertension in the participants.