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  2. Volume 9, Issue 6
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Online ISSN: 2515-8260

Volume9, Issue6

PREVALENCE OF SICKLE CELL DISORDER IN CENTRAL INDIA

    Dr. Atul Kumar Pandey, Dr. Geeta Devi, Dr. Priyanka Prajapati, Dr Rinku bhagora

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1017-1022

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Abstract

Background: Sickle cell disease (SCD) is the most prevalent monogenic inherited blood disorder worldwide, and is increasingly recognized in developing countries like India. SCD mostly occurs in rural tribal regions and low socio-economic group population
Aim: this study evaluate the prevalence of sickle cell disorder in central Indian population
Material & Methods: A cross-sectional study was carried out among 1 to 55 years age group population in a tertiary care center, Madhya Pradesh, India  Detailed information regarding the family history, socio-demographic profile was inquired. Thorough general and systemic examination was done. Haemoglobin estimation, sickling test and haemoglobin electrophoresis was performed
Results: Out of total 286 suspected patients, 277 (96.8 %) were diagnosed sickle cell disease. majority of the patients (52%) was 16-25 years age group. No significant difference between the sickling test and HPLC electrophoresis. Heterozygous state sickle cell trait (HbAS) was 206 (72%), whereas homozygous state sickle cell disease (HbSS) was 80 (28%) on Electrophoretic pattern.
Conclusion: The overall higher prevalence of sickle cell trait was found to be 96.8%.Mainly in 16-25 years age group population
Keywords:
    Sickle cell disease HPLC electrophoresis HbSS HbAS
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(2022). PREVALENCE OF SICKLE CELL DISORDER IN CENTRAL INDIA. European Journal of Molecular & Clinical Medicine, 9(6), 1017-1022.
Dr. Atul Kumar Pandey, Dr. Geeta Devi, Dr. Priyanka Prajapati, Dr Rinku bhagora. "PREVALENCE OF SICKLE CELL DISORDER IN CENTRAL INDIA". European Journal of Molecular & Clinical Medicine, 9, 6, 2022, 1017-1022.
(2022). 'PREVALENCE OF SICKLE CELL DISORDER IN CENTRAL INDIA', European Journal of Molecular & Clinical Medicine, 9(6), pp. 1017-1022.
PREVALENCE OF SICKLE CELL DISORDER IN CENTRAL INDIA. European Journal of Molecular & Clinical Medicine, 2022; 9(6): 1017-1022.
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