A hospital based prospective observational assessment of high-sensitivity C-reactive protein levels in subjects with type 2 diabetes mellitus
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 4019-4023
AbstractAim: The aim of the present study to determine the high-sensitivity C-Reactive protein levels in subjects with type 2 diabetes mellitus.
Methods: This prospective observational study was carried out in the Department of General Medicine, Rama Medical College, Mandhana for the period of 15 months. The study was undertaken on 80 type 2 Diabetes mellitus and 80 normal healthy controls. All the patients were advised to fast overnight. Blood samples were collected in fasting condition. 5ml venous blood was collected from each subject and it was transferred to the Plain tube and serum is separated by centrifugation and stored at -20 oC for measured. Estimation of Plasma Glucose by the Glucose Oxidase and Peroxidase (GOD POD) method and estimation of hs-CRP by turbidometric immunoassay using commercially available kit
Results: Fasting blood glucose, post prandial blood glucose and hs-CRP levels was measured in 80 T2DM cases and 80 age matched healthy controls. The mean and standard deviation were calculated for all the Biochemical parameters. The significance between the groups were determined using Student t-test for Equality of means. The p-value of < 0.05 was considered significant.
Conclusion: we concluded that high hs-CRP levels in T2DM cases compared with controls. hs-CRP is an inflammatory marker and has role in atherosclerosis. From this study it is observed that there is moderate correlation between hs-CRP levels and it increases the risk of atherosclerosis.
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