Formulation and Evaluation of sustained release losartan potassium microspheres
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 6, Pages 1175-1186
AbstractOral drug delivery system using sustained release microparticles preparation is a nice option for the methodology expansion and for up gradation purpose. In this present work microspheres containing Losartan potassium with different synthetic and natural polymers, gums like HPMC, PVP, Xanthan gum, Guar gum and Sodium alginate were prepared by Ionic Gelation Method. The influence of formulation factors (drug-polymer ratio and type of polymer) on the morphology, particle size distribution, drug loading capacity, micromeritics properties and the in-vitro release characteristics of the microspheres were investigated. Physical characterizations of Losartan potassium microspheres were also carried out using Scanning Electron Microscopy, and FTIR Spectrophotometry. Microspheres were evaluated for different parameters like bulk density, taped density, angle of repose and drug entrapment efficiency. In vitro dissolution studies were carried out in pH 7.4 Phosphate Buffer and 0.1N HCL buffer for about 12hrs and samples were examined by UV-Visible Spectroscopy. The results demonstrated that formulations (FA, FB, FC) showed Losartan potassium discharge speed in series of 91-94% when compared (FD, FE and FH) demonstrated a Losartan potassium discharge speed from 85. -94% to and those of (FG, FH and FI) which have displayed drug release rates in the range of 94.-98% up to duration of 12 hours. This denotes that if the quantity of rate retarding polymer is raised, then it leads to retard discharge of drug. The synergistic effect was observed when the HPMC was combined with Xanthan gum. Hence batch FH indicates the better results than batch FI. As formulation FH shown 97.78% cumulative drug release pattern when the HPMC is combined with the natural gums for retarding drug discharge. Formulation containing HPMC and Xanthan gum gave well >85%. FH batch gave 93.40%, other formulations gave little bit drug loading than this batch. It can be happened due to viscosity caused by used material best % recovery was obtained for batch FH-96.49%. Overall o% recovery of microsphere obtained > 83%.
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