Histomorphological spectrum of prostatic lesions: A prospective study on TURP specimens by using immunohistochemical marker P504S
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 6, Pages 1287-1294
AbstractAims and Objective: To study the histomorphological spectrum of non-neoplastic and neoplastic lesions of the Prostatic TURP specimens and analyse the utility of immunohistochemical marker P504S in various lesions of prostate.
Methods: This two-year prospective study on 65 transurethral resection specimens of prostate, was carried out in the Department of pathology, Dr B R Ambedkar Medical College, Bangalore. Immunohistochemical marker P504S was used and its expression in various lesions was analysed.
Results: Out of 65 cases studied, 52 (80%) were benign prostatic hypertrophy (BPH), 3 (4.6%) were non-specific granulomatous prostatitis, 1(1.5%) was prostatic abscess, 7(10.8%) were prostatic adenocarcinoma, 1(1.5%) case was urothelial carcinoma and 1 case (1.5%) had both prostatic adenocarcinoma and urothelial carcinoma. Low grade PIN was identified in 8 (12.3%) cases and all of these wereassociated with BPH. High grade PIN was seen in 9 (13.8%) cases and 7 of them were associated with adenocarcinoma. P504S marker was positive in all (100%) adenocarcinoma and 8 cases (88.9%) of High-grade PIN. Benign glands in BPH was negative for P504S.
Conclusion: BPH is the most common lesion of the prostate in the elderly and adenocarcinoma is the commonest type of prostatic carcinoma. P504S is of great value in differentiating HGPIN and malignant glands from benign glands.
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