European Journal of Molecular & Clinical Medicine

Abstract

Introduction: Dengue is one of the major re-emerging viral infections. In recent years, dengue has become a major global public health concern. In small subset of patients, there is life threatening condition with severe cytopenias and significant systemic response. The presence of macropage activation in dengue fever is well reported and could be one possible reason for mortality and morbidity. Dengue being an infective condition, a modest rise in ferritin levels and CRP are expected in dengue fever as well. In dengue fever sr. ferritin is disproportionately raised compared to any bacterial or viral infection.
Material and Methods: It was a prospective observational study conducted at MKCGMCH Berhampur over a period of 2 years from 2019 to 2021.The study population consisted of adults admitted to department of general medicine with diagnosis of dengue fever. 100 dengue patients admitted in dengue ward/to different wards of medicine department of MKCG Medical College, Berhampur were observed. Only who were seropositive for dengue fever NS1 antigen or IgM ELISA were recruited for the study. Their serum ferritin and CRP levels on the day of admission and on the fifth day were measured. The relationship between serum ferritin, CRP, platelets and severity of dengue fever was observed.
Results: Total number of uncomplicated dengue fever is 78 and that of severe dengue (DHF/DSS) is 22. The mean serum ferritin and CRP are high on day one as compared to day five, but the mean TPC on day five is high as compared to day one. Serum Ferritin and CRP are Negatively Correlated with the TPC in Linear Pattern in day one, which is statistically Significant. Serum Ferritin and CRP are Negatively Correlated with the TPC in Linear Pattern in Day Five, which is statistically significant. The mean TPC level on day one of hospitalization among DF, DHF, DSS are 79766.7, 1006.3 and 19100 respectively. The mean TPC level on day five of hospitalization among DF, DHF, DSS are 79766.7, 1006.3 and 19100 respectively. The above figures show that, the mean ferritin and CRP level on day five are significantly high among DHF/DSS as compared to DF.