European Journal of Molecular & Clinical Medicine

Abstract

Background: Laryngoscopy and intubation induce huge spectrum of stress responses such as tachycardia and hypertension. Those are in association with the surge of plasma adrenaline concentration following intubation. This study was performed to compare the efficacy of an accurate bolus dose of esmolol and bolus dose of dexmedetomidine in attenuating the pressor response to laryngoscopy and endotracheal intubation in general anaesthesia.
Materials and Methods: Randomised, comparative and double blinded study in which 30 patients were recruited in both the groups, Group D received injection Dexmedetomidine and Group Ereceived injection Esmolol assesment done for change in Heart rate, Systolic, Diastolic and mean blood pressurewith any adverse effects.
Results and Observations: Heart rate, SBP, DBP and MAP was lower in Group D as compared to Group E. No patients in either group required treatment for bradycardia and hypotension. No other adverse effects were noted in any patient.
Conclusion: Dexmedetomidine is effective in attenuating hemodynamic response to laryngoscopy and tracheal intubation without any side effect.