European Journal of Molecular & Clinical Medicine

Abstract

Introduction: The postoperative pain can have a significant effect on patient’s recovery and increases hospital stay and cost of care. Hence, this study was conducted to compare post-operative analgesia in the group with lignocaine and a group with combination of lignocaine and magnesium sulphate by NRS score at 0, 2, 4, 12 and 24 hour and to compare hemodynamics between the two groups intra-operatively and post operatively.
Materials and Methods: In this prospective, randomized, double-blind, controlled trial, 100 patients were enrolled. The study was conducted by the Department of Anesthesiology, Indira Gandhi institute of Medical Sciences, Patna, Bihar. The study was approved at the Institutional Ethics Committee. The time period of the study was six months. Selected patients were randomly allocated to two groups, each containing 50 patients. Group A patients received only intravenous lignocaine 2mg/kg in bolus in 50 ml Normal saline and maintained at the rate of 3mg/kg/hour. Group B patients received the combination of intravenous lignocaine and magnesium sulphate 50mg/kg in bolus of 50 ml Normal saline and maintained at the rate of 15 mg/kg/hour and lignocaine at same dose.
The postoperative pain was estimated with two tools; consumption of analgesic during postoperative period and the time to request them. Each patient was assessed using NRS score which varies from 0 to 10 where 0 means no pain 10 means intolerable pain. Statistical analysis was done using Microsoft Excel.
Results: We found that a combination of lidocaine and magnesium sulfate resulted in significantly lower analgesic consumption. We also also found that lidocaine had lower pain score than Mg group, though statistical significance could not be established.
Conclusions: Hence, we concluded that usage of IV MgSO4 followed by continuous infusion leads to decrease in postoperative pain and analgesic consumption in patients undergoing laproscopic cholecystectomy.