European Journal of Molecular & Clinical Medicine

Abstract

Cardiovascular disease is the leading cause of mortality in the world. There are several risk factors for cardiovascular disease, such hypertension, dyslipidemia, obesity, diabetes mellitus and cigarette smoking. However, these classic risk factors do not entirely explain for future cardiovascular disease. As a result, many newer risk factors such as estimated glomerular filtration rate (eGFR), microalbuminuria, C-reactive protein (CRP), homocysteine have been evaluated as potential predictive factors. Microalbuminuria is gaining recognition as simple marker of atherogenic risk. Positive albuminuria is considered not only marker of renal damage but also signify systemic vascular damage since.  In this study we want to evaluate the association between albuminuria and coronary atherosclerosis using angiography in cases with type 2diabetes mellitus by estimating urinary albumin excretion. Materials and methods: It is a cross sectional, observational study of association between increased Albuminuria and Coronary Atherosclerosis in 100 patients with Type 2 diabetes mellitus. We exclude the patients with Gestational diabetes mellitus,type 1 diabetes mellitus and urinary tract infection. Results: Prevalence rates for microalbuminuria in the present study were 31%. 41-50 years showed maximum of microalbuminurics followed by 51-60 years group had maximum of macroalbiminuria cases. Most of the patients were detected with microalbuminuria and in the first few years of the disease. Patients falling in the overweight category showed maximum number of micro and macroalbuminurics. Lipid Profile abnormalities showed negative correlation with microalbuminuria but positive with Serum Triglyceride levels. Due to CAD examination, Microalbuminuria cases were higher as 54.8% among those with DVD. Conclusion: Microalbuminuria in itself being a predictor of diabetic nephropathy however it shows negative association with diabetic neuropathy and diabetic retinopathy. Microalbuminuria showed positive association with CAD cases in the present study. Hypertension and dyslipidemia being a cardiovascular risk factor showed a significant association with microalbuminuria