Assessment of effects of Succimer and Penicillamine on acute lead poisoning patients
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 2957-2961
AbstractBackground: Lead is among the oldest known toxins; lead poisoning is a dangerous environmental and occupational disease. The present study was conducted to assess effects of Succimer and Penicillamine on acute lead poisoning patients.
Materials & Methods: 75 patients of acute lead poisoning of both genders were divided into 3 groups of 25 each. Group I received D-Penicillamine (250 mg every 6hours orally for two weeks), group II D-Penicillamine with succimer (250 mg every 6hours orally for two weeks + 200mg every 6 hours orally for two weeks and group III succimer(10 mg/kg for the first 5 days every 8 hours, then every12 hours up to 14 days). Parameters such as symptoms, length of hospitalization (day), blood pressure, heart rate and outcome of the treatment was recorded.
Results: Symptoms observed were nausea & vomiting in 12, 8 and 7, abdominal pain in 15, 11 and 9, constipation in 10, 12 and 11, fever in 9, 3 and 8, skin rash in 11, 7 and 9 and weak plantar reflex in 13, 11 and 10. Outcome was recovery in 23, 25 and 25 and death in 2 in group I, group II and group III respectively.The mean length of hospitalization was 2.7 days in group I, 3.9 days in group II and 3.5 days in group III. Systolic blood pressure was 134.2 mm Hg in group I, 130.2mm Hg in group II and 132.6mm Hg in group III. Diastolic blood pressure was 84.5 mm Hg in group I, 80.2mm Hg in group II and 82.6mm Hg in group III. Heart rate (beats/minute) was 90.2, 88.4 and 90.8 in in group I, II and III respectively. The difference was non- significant (P> 0.05).
Conclusion: Succimer and Penicillaminefound to be equally effective in acute lead poisoning patients.
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