Xanthogranulomatous Cholecystitis: A Malignant Masquerade- A Retrospective Study of a Tertiary Care Centre
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 3748-3754
AbstractBackground: Xanthogranulomatous cholecystitis (XGC) is a variant of chronic cholecystitis characterised by giant cells, foamy macrophages, and chronic inflammatory cell infiltration resulting in mass formation and adjacent organ invasion. These characteristics make it difficult to differentiate it from Gallbladder cancer (GBC). Our aim was to study the incidence of XGC mimicking a gallbladder mass in operated patients of GBC in a tertiary care centre.
Materials and Methods All patients who have undergone surgery for operable GBC were included in the study and patients with histopathological confirmation of XGC were analyzed.
Results Out of 59 patients who underwent radical cholecystectomy for a preoperative diagnosis of GBC, the histopathology of 9 patients was reported as XGC, 3 males and 6 females with a mean age of 46.9 years. All patients except one had an uneventful recovery. One patient had a postoperative bleed and had to be reexplored. All patients had an uneventful post-discharge course with none requiring a readmission for recurrent symptoms
Conclusion XGC is not an uncommon entity mimicking GBC. With no consistent imaging findings to categorically establish the preoperative diagnosis of XGC, it is advisable to manage the gallbladder mass as malignancy to avoid the disaster of a missed malignancy
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