Abstract

Background: Gatrointestinal stromal tumor (GIST), now the most common mesenchymal tumor of the gastrointestinal tract(GIT), has been frequently studied.
Objectives: Our aim was to study histopathology, demographic profile, histopathological grading, IHC property and behavior of  Gastro intestinal stromal tumor(GIST)
Material & Methods: Retrospectively 50 cases were selected& studied from the department of histopathology of tertiary care hospital,  Ahmedabad, India during  june 2010 to june 2013
Results: 50 cases were studied in our study. Most common site was stomach(40%)followed by jejunum(18%), rectum(16%)& ileum(12%). Most common age group was 51-60 years. Most common presenting symptoms  was abdominal pain (70%)  Seventy  percent of  Gastrointestinal stromal tumor were positive for CD 117(KIT). Histologically majority of them had a pure spindle cell morphology. Eight patients (21%)  had  recurrent /residual  mass of presentation.
Conclusion: In our study large number of  Gastro intestinal stromal tumor were present in the stomach. Most common age group was 51-60 years. Majority of  them  were of pure spindle cell morphology. Molecular studies and larger numbers of cases are required for meaningful conclusion to be drawn.