The diagnostic utility of commercially available rapid IgM kit tests in comparison with MAC-ELISA IgM in the diagnosis of chikungunya in children
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 6, Pages 2383-2387
Clinical manifestations of CHIK are non-specific and difficult to differentiate from dengue hemorrhagic fever or other viral exanthema, so it is necessary to confirm by reliable laboratory investigation. The increasing threat of CHIKV emergence in temperate regions and the need to anticipate possible outbreaks of CHIKV infection are presenting a challenge to the current level of diagnostic preparedness. Ethical clearance was obtained from Institutional Review Board. Children who fulfilled the inclusion criteria were enrolled. Informed consent was obtained from all patients or from parents or guardians of all cases. All enrolled children's details of demography, clinical data including symptoms and onset and duration of fever, findings of general as well as systemic examination and laboratory parameters were recorded in a predesigned proforma. The sensitivity of Kit 1 was 0.00% (95% CI 0.0- 10.72%) and specificity was 98.53% (95% CIs 92.13-99.74%) with positive predictive value of 0.00% and negative predictive value of 67.68%. The sensitivity of Kit 2 was 3.13% and specificity was 100% with positive predictive value 0f 100% and negative predictive value of 68.69%.
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