European Journal of Molecular & Clinical Medicine

Abstract

Aim: To determine the role of risk factors for increased morbidity and mortality  in perforated peptic ulcer
Methods and materials: All patients aged 18 and above who had abdominal surgery for PPU were included in this research. Intravenous fluids, nasogastric suction, and intravenous antibiotics were then administered to the patients. After proper resuscitation, the perforation site was located and a laparotomy was performed via a midline incision. The hole was simply closed and reinforced with a pedicle omental patch. Peritoneal lavage with 4 to 5 litres of normal saline was performed. An intraperitoneal drain is placed at the discretion of the operating surgeon. All patients were placed on a double antibiotic regimen that included Ceftriaxone (1gm bid), Metronidazole (500 mg tid), and Omeprazole (20 mg bid). Patients were monitored for up to six months following surgery. The research covered morbidity and mortality during the hospital stay as well as the following 6-month follow-up