EMERGENCE OF NON-ALBICANS CANDIDA SPECIES IN NEONATAL CANDIDEMIA
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 4007-4012
Abstract
Aim: Therefore, following study was conducted to know the occurrence of candidemia in our region, among suspected septicemic patients.Materials and Methods: This prospective study was conducted between december and april 2017 in the Departments of Microbiology and Pediatrics of tertiary care hospital in central , India. From a total 110 neonates admitted to NICU with clinical suspicion of septicaemia. blood samples were collected in blood culture bottle and incubated at 37C .then subculture done on blood agar and Mc conkey agar and Sabouraud’s dextrose agar with chloramphenicol (0.05%) and incubated at 37C. Only those which yielded pure growth of candida spp. Were included in the study. Preliminary identification was done by colony morphology on SDA , chromogenic medium, growth at 45C , germ tube test , chlamydospore formation and was confirmed by carbohydrate fermentation test. Candidemia was defiend as the presence of at least one positive blood culture containing pure growth of candida spp. With supportive clinical feature.
Results- Total 110 neonates included in the study, 65(59%)were females and 45(41%) were males.candida albicans responsible for 67% cases while NAC species responsible for 33% cases with12% cases by C. tropicalis, 10% cases by C.parapsillosis, 5% by C. gullermondii, 4% by C. krusei, 2% by C.kefyr. among the risk factors observed for candedimia prematurity and LBW , indwelling catheters are commonest followed by broad spectrum antibiotic use, TPN prolonged hyperalimentation. Various clinical presentations also seen in candidemia.
Conclusion-
Candidemia in neonates is an ominous prognostic sign and is an important entity in our hospital. Preventive measures such as use of filters for parenteral nutrition, prophylactic antifungal use, and a restrictive policy of antibiotic use to decrease Candida colonization/ infection rates should be implemented to reduce the morbidity and mortality associated with these infections.
Keywords:
- Article View: 13
- PDF Download: 27