Clinical & histological profile of patients with nonalcoholic fatty liver disease
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 4013-4019
AbstractBackground: The estimated prevalence of fatty liver in the general population averages around 14-25 % with rising prevalence in the presence of risk factors. Liver biopsy continues to be the ultimate and specific investigation for assessing the nature and severity of a spectrum of liver diseases. Present study was aimed to study clinical & histological profile of patients with nonalcoholic fatty liver disease.
Material and Methods: This study was retrospective and prospective, observational study, conducted in patients with increased echo texture of liver on routine ultra-sound scan, suggestive of fatty liver disease, prior to performing percutaneous liver biopsy, the proper preparation of a patient is important, with attention to a detailed knowledge of the procedure, a complete history and physical evaluation, medication use, and fresh clotting parameters.
Results: In present study, among 60 patients, 36 (60%) were females and 24(40%) were males. Majority were from the age group of 41- 50 years (36.66%), followed by 51-60 years (30 %). Commonest symptom was fatigability and malaise (66.66%), followed by right upper abdominal discomfort (46.66%), Jaundice (10%), ascites (10%), UGI Bleed (8.3%) patients and 20 (33.33%) patients were asymptomatic at the time of diagnosis. The commonest clinical sign was of hepatomegaly or palpable liver (90%), edema (35 %), abdominal distension (18.33 %), splenomegaly (16.67 %) & icterus (13.33 %). Various risk factors noted were dyslipidemia (61.67 %), diabetes mellites (58.33 %), hypertension (53.33 %), overweight (50 %), obese (46.67 %) & coronary artery disease (40 %). 7 patients underwent biopsy. Of these 4.28% patient showed steatohepatitis, 42.86% patients showed simple fatty change and 14.28% patient had cirrhosis. Other 28.57% had no specific changes.
Conclusion: Our findings were consistent with the earlier concept that non-alcoholic steatohepatitis was prevalent in obese females with diabetes and hyperlipidemia.
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