Abstract

Background: The incidence of Chronic Kidney Disease Stage-V and dialysis population requiring renal transplantation is increasing globally. Present study was aimed to evaluate the efficacy and safety of low dose continuous infusion of dexmedetomidine on hemodynamic changes, sedation and analgesic requirement intraoperatively and immediate postoperatively in patients undergoing for renal transplantation.
Material and Methods: Present study was single-center, Randomized, prospective, double blind, placebo-controlled study, conducted patients, age between 18-60 years undergoing renal transplantation, ASA grade 2 and 3. Patients were assigned into 2 groups, as study Group (continuous infusion of dexmedetomidine at rate of 0.2 mcg/kg/h) & control Group.
Results: Among both groups, distribution of age, gender, weight, Mallampatti grades, comorbidities, mean duration of surgery, mean duration of anaesthesia were comparable & no statistically significant difference was observed (p> 0.05). Mean heart rate was lower in study group as compared to the control group and significant differences were found at all-time points of the study period (p < 0.05).  SBP & DBP after 15 minutes of induction decreased significantly from the base line value in study group, and this lasted throughout the intraoperative period till the end of surgery, the difference being statistically significant (p < 0.05) Postoperatively, SBP & DBP in the study group were less than the SBP & DBP in control group at all the time points & difference being statistically significant (p < 0.05).