Mean platelet volume to lymphocyte ratio as a novel marker for diabetic nephropathy
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 4086-4091
Abstract
Aims: The present study was designed to compare Mean platelet Volume to Lymphocyte ratio (MPVLR) as predictor of inflammatory marker in patients with Diabetic nephropathy and diabetics without nephropathy.Materials & methods: The study was conducted on 50 diabetic patients with nephropathy and 50 diabetics without nephropathy that presented to Medicine department (indoor/ outdoor department) of Guru Nanak Dev Hospital, Amritsar. The subjects were divided into two groups i.e. Group A and Group B. Group A comprised of 50 Diabetic patients with Nephropathy and Group B comprised of Diabetic patients without Nephropathy. Detailed history was taken and all patients underwent a detailed clinical evaluation including measurement of vitals. Plasma glucose, Blood urea, Serum creatinine were estimated by standard protocols. Urine complete examination was done microscopically. Albuminuria, which is the hallmark of diabetic nephropathy, was estimated using spot Urinary Albumin-creatinine ratio (UACR). The quantitative determination of microalbuminuria was done by Nephelometry method procuring commercially available kits. Mean Platelet Volume (MPV) and Absolute Lymphocyte Count (ALC) were calculated using cell counter (ABX Pentra 80) and then ratio was calculated by dividing MPV to ALC.
Results: In Group A, mean MPV was 10.46 fL while in Group B, it was 8.60 fL. The mean MPV in Group A was significantly higher as compared to Group B (p = 0.001). Mean Absolute Lymphocyte count (ALC) in Group A was 2.03x10^3/µL, while in Group B was 2.80x 10^3/µL. The mean MPVLR was 5.27 and 3.08 in Group A and Group B respectively and the difference was found to be statistically significant (p=0.001).
Conclusion: MPVLR values are higher in patients with diabetic nephropathy and this difference is statistically significant. MPVLR is easily available; cost effective and routinely done, hence, it can be considered as a novel marker for Diabetic nephropathy (DN)in diabetic patients
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