A New Approach to Drug Delivery Using In-Situ Gel for Stomach-Specific Sustained Absorption
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 4497-4516
Abstract
Floating in-situ forming polymeric formulations are drug delivery systems that are in sol form before being supplied to the body, but then gel in-situ to form a gel after being injected. Temperature modulation, pH alteration, presence of ions and ultraviolet irradiation, electrical sensitivity, and enzyme sensitivity are all elements that influence the creation of gels, from which the medication is released in a controlled and sustained manner. Controlled and sustained drug administration has recently become a popular strategy in modern pharmaceutical design, with extensive research being conducted to improve medicinal product performance, reliability, and safety.The in-situ gel forming polymeric formulations have various advantages over conventional drug delivery systems, including sustained and prolonged action, strong patient compliance, and good durability and biocompatibility features, making in situ gel dosage forms very trustworthy. Gellan gum, sodium alginate, HPMC (hydroxypropyl methylcellulose), xyloglucan, pectin, chitosan, poly (DL lactic acid), poly (DL-lactide-co-glycolide), and poly-caprolactone are some of the biodegradable polymers used to make in situ gels. Sol-gel transition temperature and floating lag time of gel, in-vitro drug release tests, gel strength, viscosity & rheology, and clarity are all factors to consider when evaluating in-situ gel systems. Recent advances in polymer science and technology have resulted in the development of a variety of stimuli-sensitive hydrogels, such as pH and temperature-sensitive hydrogels that are employed for the targeted delivery of proteins to the colon and chemotherapeutic drugs to cancers. The in-situ gel dosage forms are particularly reliable due to the drug's sustained and prolonged release, as well as its good stability and biocompatibility- Article View: 51
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