Assessment of relationship between serum uric acid and ejection fraction of the left ventricle
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 4688-4692
AbstractBackground: It has been proved that the prevalence of reduced ejection fraction heart failure (refHF) is decreasing, with a stabilization of mid-range ejection fraction heart failure (mrHF) prevalence and rise in number of patients with preserved ejection heart failure. The present study was conducted to assess relationship between serum uric acid and ejection fraction of the left ventricle.
Materials & Methods: 48 patients of chronic heart failure of both gendersunderwent cardiac ultrasound. Measurement of planimetric ejection fractions and left atrial volume were taken. Patients were divided into 3 groups based on ejection fraction. Group I had EF >50%, group II between 40-49% and group III had <40%. 5 ml venous blood samples were taken, and measurements of biochemical parameters such as serum electrolytes (Na+ and K+), serum creatinine (SC), and a lipid panel and serum uric acid (SUA) were performed. SUA was measured. NT-proBNP levels were also measured for all patients.
Results: Out of 48 patients, males were 30 and females were 18. The mean Na+ (mmol/L) was 139.2, 139.4 and 139.1, K+ (mmol/L) was 4.5, 4.7 and 4.9, S. creatinine (mg/dL) was 1.5, 1.6 and 1.9, eGFR (MDRD) (mL/min) was 46.7, 42.3 and 42.1, S. uric acid (mg/dL) was 7.9, 7.1 and 7.5, NT-proBNP was 2456.3, 3654.3 and 6714.5 and LAV (mL) was 64.2, 81.4 and 103.5 in group I, group II and group III respectively. The difference was significant (P< 0.05).
Conclusion: There was association of increased serum uric acid with the level of the ejection fraction of the left ventricle.
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