Evaluation of endocrinopathies among male thalassemic children attending a tertiary care centre in north India
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 5015-5020
AbstractIntroduction: Thalassemia is a group of disorders resulting from an inherited defect in the rate of synthesis of one or more globin chains. Endocrine abnormalities in thalassemia major are common alarmingobstacles which require prompt management.
Objective: To know the prevalence and pattern of endocrinopathies among thalassemicmale children (N=85) within 6months to 18 years of age attending thalassemia day care centre in department of paediatrics GMC, Jammu.
Results: All of the patients (98.8%) had thalassemia major; minor type of thalassemia was present in one patient only. Hypothyroidism and hyperthyroidism were present in 7% and 2% patients, respectively. Majority (69.41%)of the patients had lower Vitamin B12 level. Diabetes mellitus was absent. All patients had reduced haemoglobin level. Testosterone level was also normal. Among male children ≤ 10 years, only megaloblastic anaemia was present in 72.09% patients. In male children >10 years age, megaloblastic-anaemia and Hypothyroidism were noted in 66.66% and 7.14% patients respectively.
Conclusion: Our study throws some light on the endocrinal complications associated with thalassemia and adds to the already existing literature about the prevalence of endocrinopathies among thalassemic patients.
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