European Journal of Molecular & Clinical Medicine

Abstract

Objectives: At present, serum amylase and lipase are the most widely used laboratory markers for early diagnosis of acute pancreatitis with reasonable sensitivity and specificity. Recently the significance of urinary trypsinogen-2 in the diagnosis of the acute pancreatitis has identified and its usage was increased but its sensitivity and specificity of the test for the diagnosis of acute pancreatitis has not yet been sys assessed.
Data sources: Patients presenting with acute upper abdominal symptoms like
pain, vomiting, abdominal distention, admitted in the emergency department of our hospital from december 2020 to june 2022 are enrolled in the study. Urine sample were obtained from all the patients and tested with spot Urine trypsinogen-2 dipstick. Serum amylase and serum lipase tests were also simultaneously done in these patients.
Results: Sensitivity of amylase and lipase was found to be 73.77% and 59.02% respectively, whereas as sensitivity of trypsinogen was found to be 78.69%. Specificity of amylase and lipase was found to be 89.74% and 89.74% respectively, whereas as specificity of trypsinogen was
found to be 92.1%. Analysing the data, it is found that sensitivity and specificity of trypsinogen is higher than the routine investigations.
Even though it has a low range of sensitivity, its high specificity ensures that the test can be used as a screening test to check the true negative cases.
Conclusions: UT-2 as a rapid test could be potentially used for the diagnosis of acute pancreatitis. Further studies are warranted to confirm these results.