European Journal of Molecular & Clinical Medicine

Abstract

Introduction: The extracellular matrix remodeling is an important step in primary tumor growth, and metastasis. Many studies regarding carcinomas, including breast carcinoma, have suggested elevated levels of procoagulant factors and fibrinogen and fibrin degradation factors and associated fall in coagulation system inactivators. In the current study we try and correlate the coagulation markers D-dimer, Factor VIII, PT & INR in carcinoma breast patients, with advancing stages of the disease and lymph node metastasis and to look for the relation of these coagulation markers with know prognostic factors in carcinoma breast.
Methods: A total of 100 subjects (Diagnosed cases of operable carcinoma breast) were enrolled in the study from the Department of Surgery, Krishna Hospital, Karad, over the period  December 2020 to July 2022.
Results:  The above study had a mean age of 53.33yrs, with marority of the cases being of left sided breast carcinoma (58%), with majority of them belonging to the stage IIA (33%).  There was a statistically significant correlation between  the coagulation markers  D-dimer, Factor VIII, PT and INR; with progressive stage of carcinoma breast  with p value= 0.024, p value= 0.05, p value= 0.023 respectively. There was a statistically significant decrease in the coagulation markers that were noticed postoperatively (PT p value= 0.03, INR p value=0.0008, D-Dimer p value= 0.016, and Factor VIII p value=0.001 respectively.)
Conclusion: There is a statistically significant correlation between  the coagulation markers  D-dimer, Factor VIII, PT and INR; with progressive stage of carcinoma breast