Formulation Development of Liposomal Gel of Umbelliferon for Topical Application
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 5564-5573
AbstractThe main objective of this formulation was to prepare characterized and evaluate the liposomal gel containing Umbelliferon for topical site. The Umbelliferon is insoluble in water and poorly absorbed in orally routes. This problem can be overcome by the formulation of liposome gel and gives the effective therapeutic action. Umbelliferon is used for the topical treatments and to possess a wide range of biological activities including anti-inflammatory, antioxidant, antifungal activities etc. Umbelliferon is used to formulate liposomal gel for topical sites.
The liposomal gel was prepared by using different polymers. The rate of absorption was increased by incorporating the drug (Umbelliferon) into the phospholipid and cholesterol in the solvent like (chloroform and methanol) which was prepared by rotary evaporator method. The liposome gel was evaluated for % yield, particles size, % drug content, in-vitro study. Further, the liposomal gel was prepared with optimize liposomal gel formulation and it was evaluated. The percentage product yield was found in the range of 56±3.7 to 84 ± 4.2 of F1 to F6 Liposomal gel formulations. The size of vesicles was found from 1521±1352 to 312.3±124.5. The pH was found between the ranges of 5.4±0.3 to 7.7±0.3. The Speadability was found to range from 3.9±0.2 to 6.9±0.9. The viscosity of gel was found range from 4853±412 to 18698±562.The drug content was found to range from 60.8±0.7% to 80.3±0.7%.
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