The Comparative study of Homocysteine level and its association with lipid profile in smoker and Non smoker healthy adults of Udaipur city
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 5900-5908
AbstractBackground: Smoking is strongly and independently associated with cardiovascular disease and is the biggest single avoidable health habit contributing to chronic diseases in the western world.
Objectives: The objective of this study is to find out the correlation of lipid profile & Homocysteine and their comparison in smoker and non-smoker.
Methodology: Total 300 patients were include in this study, in which patients ranging within age 20-40 years, they were further categorized according to use of tobacco smoking. Group A- This group consist of tobacco smoker patients between ages 20- 40 years. (n=150).Group B-This group consist of tobacco non-smoker patients between ages 20-40 years. (n=150). 10 ml blood was drawn through vein puncture. From all collected blood samples serum lipid pofile, Liver function test and Homocysteine levels measured. All collected data were analysed statistically to calculate p value to see the difference of significance.
Results: The Mean concentration of Total cholesterol in smoker group was 205.31 ±39.47 while that of Non smoker control group 189.69 ±36.81 and the difference among them found to be highly significant .The Mean concentration of S.HDL in smoker group was 35.3±7.89 and 42.56±39.85 in Nonsmoker group respectively and the difference among them found to be highly significant. similar to that S.LDL concentration in soker group was 128 ±30.57 and in non smoker group 115.31 ±26.27 and difference among them found to be highly significant . Serum Triglyceride concentration in case group was 170.10±25.60while that of control group 147.21 ± 67.36 and p value is <0.001 so the difference among them is also significant.The Mean concentration of S.homocysteine in smoker group was 27.32±17.41 and 6.66±3.09 in control group and the difference among them found to be highly significant.
Conclusion: In conclusion, smoking produces adverse effects on lipid profile and homocysteine, thus increasing the cardiovascular disease risk. Further studies are needed to establish that smoking-related alterations have influences on the atherosclerotic lesions of smokers
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