European Journal of Molecular & Clinical Medicine

Abstract

Background: Smoking is strongly and independently associated with cardiovascular disease and is the biggest single avoidable health habit contributing to chronic diseases in the western  world.
Objectives: The objective of this study is to find out the correlation of lipid profile & Homocysteine and their                                           comparison in smoker and non-smoker.
Methodology: Total 300 patients were include in this study, in which patients ranging within age 20-40 years, they were further  categorized according to use of tobacco smoking. Group A- This group consist of tobacco smoker patients between ages 20- 40 years. (n=150).Group B-This group consist of tobacco non-smoker patients between ages 20-40 years. (n=150). 10 ml blood was drawn through vein puncture. From all collected blood samples serum lipid pofile, Liver function test  and Homocysteine levels measured. All collected data were analysed statistically to calculate p value to see the difference of significance.
Results: The Mean concentration of Total cholesterol  in smoker  group was  205.31 ±39.47 while that of  Non smoker control group 189.69 ±36.81 and the difference among them found to be  highly significant .The Mean concentration of S.HDL  in smoker group was 35.3±7.89 and 42.56±39.85 in Nonsmoker  group respectively and the difference among them found to be  highly significant. similar to that  S.LDL concentration in soker group was 128 ±30.57 and in non smoker  group 115.31 ±26.27 and difference among them found to be  highly significant . Serum Triglyceride  concentration in case group was 170.10±25.60while that of control group 147.21 ± 67.36 and p value is <0.001 so the difference among them is also  significant.The Mean concentration of S.homocysteine in smoker  group was 27.32±17.41 and 6.66±3.09  in control group and the difference among them found to be  highly significant.
Conclusion: In conclusion, smoking produces adverse effects on lipid profile and homocysteine, thus increasing the cardiovascular disease risk. Further studies are needed to establish that smoking-related alterations have influences on the atherosclerotic lesions of smokers