A study on detrimental effect of antiepileptic drugs dose in pediatric children
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 6008-6017
AbstractIntroduction: Adversity of epileptic drugs is still unwanted and inseparable along with advantages of epileptic medication, despite much progress has been made in the area of anti-epileptic drugs (AEDs) development. Therefore, the aim of this study was to compare the effectiveness of AED under BNF guidelines and regular practice for different oral antiepileptic medications in enhancing and controlling the patient’s disease state and tolerability.
Material and Methods: All the patients (70) were randomly divided into two groups; group I patients were on regular practice medication While, group II patients followed British National Formulary (BNF) guideline. The Pediatric Quality of Life Inventory (PedsQL) was used to assess the adverse effects in epileptic patients.
Results: Results revealed that 23.5% patients of Group II patients followed BNF had seizures whereas, 53.1 % patients of group I who followed regular practice had convulsion after 6 months follow up. Patients on levetiracetammonotherapy were experiencing poor seizure control with a number of seizure incidence in group I patients (n=10) compared to patients (n=4) who followed the BNF guidelines. Adverse effects were more in 65.6% patients of group I following regular practice medicines (n=21) compare to 23.5% patients (n=8) of group II followed BNF guidelines.
Conclusion: The present study concluded that unbiased individualization of patients for the selection AEDs and its doses according to BNF guidelines has been found significantly effective in reducing the adverse effects as well as improved seizure control in pediatric population.
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