Qualitative and Quantitative Dermatoglyphics and the Estrogen Exposure in Breast Cancer Risk: an Epigenetic Context.
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 480-490
Abstract
Background – The lastingness of dermatoglyphics suggest epidermal ridges as a bio-signature for studying the epigenetic insults in the prenatal period. Approaching the preventive measures in epigenetic viewpoint aid to reduce the incidence of carcinoma. Objective – To inquire the association of qualitative and quantitative dermatoglyphics and the estrogen exposure in spotting out breast cancer risk in an epigenetic context. Materials and Methods – We performed the study among 150 females in three groups. The outcome of dermatoglyphic variables includes six or more whorls, Mean finger ridge count, A- B Subtotal ridge count, ATD angle and pattern intensity index. The variables of reproductive and genetic factors are increased menstrual age, Nulliparity, First Full Term Pregnancy >30yrs, and Positive Family History. The statistical procedure used are odds ratio and the level of significance using P- value. Results - Increased menstrual age is significantly associated with six and more whorls (P<0.0001), Mean finger ridge count (P<0.04), A-B Ridge count (P<0.0001), ATD angle (P<0.0001), Pattern intensity index (<0.0001). Nulliparity is significantly associated with the ridge count (P<0.0001), ATD angle (P<0.001), full term pregnancy >30yrs is associated significantly with A-B ridge count (P<0.01), ATD angle (P<0.02), pattern intensity index (P<0.05).Positive Family History is associated significantly with all the variables. Conclusion: To encapsulate six or more whorls are associated with high frequency with positive family history, Mean finger ridge count, and pattern intensity index is related in high frequency with menstrual age and ATD angle is linked in high frequency with nulliparity when compared with other reproductive factors.
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