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In vitro examination of the role of exercise-induced serotonin replication in the prevention and advancement of liver cancer via the intrinsic apoptotic signalling pathway.

    Authors

    • Ashfaaq Ahmed 1
    • Lavanya Prathap 2
    • Selvaraj Jayaraman 3
    • Preetha. S 4

    1 Department of Anatomy Saveetha Dental College and Hospitals Saveetha Institute of medical and technical sciences Saveetha university, Chennai - 600077

    2 Associate Professor Department of Anatomy Saveetha Dental college and hospitals, Saveetha institute of medical and technical sciences Saveetha university, Chennai - 600077

    3 Associate Professor Department of Biochemistry Saveetha Dental college and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha university, Chennai - 600077

    4 Assistant Professor Department of Physiology Saveetha Dental college and hospitals, Saveetha institute of medical and technical sciences Saveetha university, Chennai - 600077

,

Document Type : Research Article

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Abstract

Background: Serotonin is an important mediator of variety of physiological processess including fibrogenesis,steatosis,cell proliferation. It functions as a neurotransmitter and vasoconstrictor. In this study we explained the influence of physical exercise which induces serotonin in modulating liver cancer and its functions as a neurotransmitter that inhibits the growth of tumors in a concentration dependent. Hence they are less likely to develop liver cancer through an intrinsic apoptotic signaling pathway through three  genes ( Bcl-xl, Bcl-2, p53).
Aim: To analyze Influence of exercise induced serotonin replica in prevention and progression of liver cancer through intrinsic apoptotic signaling pathway.
Materials and methods:
Human liver cancer cell line (HEPG2) was brought from NCCS, Pune, India. Cell viability test for seratonin and Gene expression analysis were carried out for The p53, Bcl-xl, Bcl-2 mRNA gene expression using MTT and PCR respectively. The results were analyzed using appropriate statistical tools.
Results: The p53 mRNA gene expression is increased on induction of 2mM, 4mM dosage of serotonin. Bcl-xl, Bcl-2 and % of cell viability decreases on induction of serotonin. Hence the compound has anti - cancer activity.
Conclusion: The results of the study concluded that people who exercise regularly have endogenous secretion of serotonin that inhibits tumor growth through modulating apoptotic and signaling pathways and hence they are less likely to develop liver cancer.

Keywords

  • Serotonin
  • neurotransmitter
  • apoptotic pathway’ Bcl-2
  • Bcl-xl’ p53
  • innovative method
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European Journal of Molecular & Clinical Medicine
Volume 9, Issue 8 - Issue Serial Number 8
December 2022
Page 560-568
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  • PDF Download: 70

APA

Ahmed, A., Prathap, L., Jayaraman, S., & S, P. (2022). In vitro examination of the role of exercise-induced serotonin replication in the prevention and advancement of liver cancer via the intrinsic apoptotic signalling pathway.. European Journal of Molecular & Clinical Medicine, 9(8), 560-568.

MLA

Ashfaaq Ahmed; Lavanya Prathap; Selvaraj Jayaraman; Preetha. S. "In vitro examination of the role of exercise-induced serotonin replication in the prevention and advancement of liver cancer via the intrinsic apoptotic signalling pathway.". European Journal of Molecular & Clinical Medicine, 9, 8, 2022, 560-568.

HARVARD

Ahmed, A., Prathap, L., Jayaraman, S., S, P. (2022). 'In vitro examination of the role of exercise-induced serotonin replication in the prevention and advancement of liver cancer via the intrinsic apoptotic signalling pathway.', European Journal of Molecular & Clinical Medicine, 9(8), pp. 560-568.

VANCOUVER

Ahmed, A., Prathap, L., Jayaraman, S., S, P. In vitro examination of the role of exercise-induced serotonin replication in the prevention and advancement of liver cancer via the intrinsic apoptotic signalling pathway.. European Journal of Molecular & Clinical Medicine, 2022; 9(8): 560-568.

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