ROLE OF ENDOGENOUS GLUTATHIONE AS REGULATOR OF WNT/BETA CATENIN SIGNALLING RELEVANT TO BREAST CANCER - A MOLECULAR DOCKING STUDY
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 578-592
AbstractBackground: Breast tumor is the most common tumor in women and the second leading cause of tumor death in women, after lung tumor. As people get older, their chances of developing breast tumor increase. Breast tumor is a major health concern in developed countries. Glutathione is an endogenous antioxidant that helps maintain quality of life and may help prevent breast tumor. The role of endogenous glutathione as a regulator of Wnt/beta catenin signalling in breast tumor will be studied using molecular docking.. Materials and Methods: The molecular docking analysis is a bio-informatic study executed in a dental college. The endogenous substance Glutathione which is secreted after exercise is used as a target protein. The interaction of glutathione with proteins relevant to breast tumor namely Beta catenin , MYC are included for docking analysis. The protein structure is retrieved using protein data bank, Protein protein docking done using patch dock server followed by visualisation of protein- protein interaction using pymol. Results: The surface representation of Glutathione with Beta-catenin,MYC complex showed good shape complementarity. The number of structurally aligned residues indicates anticipated binding free energy for the top-listed solutions. Conclusion: The findings suggest that exercise-induced endogenous glutathione may operate as a regulator of wnt/beta catenin signalling in breast tumor. The exercise may help maintain gene expression balance by modifying the Wnt/beta catenin signalling system, as well as operate as a protective factor in preventing, controlling, and aiding as an additional therapy for breast tumor with a favourable prognosis.
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