Sensory nerve conduction velocity changes in low level laser therapy irradiated diabetic neuropathy induced wistar rats
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 659-673
AbstractBackground: Management of Diabetic neuropathy with physiotherapy is very limited and extensive research has to be done to address this problem conservatively in a physiotherapy perspective. The aim of the study is to analyze the effect of various dosage of low level laser irradiation on sensory nerve conduction velocity (SNCV) of experimentally induced diabetic neuropathy in wistar rats. Materials and Methods: We performed a randomized controlled trial using simple random sampling method in a CPCSEA Approved, Biomedical Research Unit & Laboratory Animal Centre, Chennai, India. The study carried out in two phases, in the phase I the selected experimental rats are treated with single dose on Alloxon 150mg/kg body weight after 12 hours of fasting. In the Phase II the samples with confirmed neuropathic status were divided into seven groups (six rats in each group) and irradiated with low level laser therapy with various dosages Results: The SNCV result analysis within the groups showed that laser dosage of 3,4j/cm2 are having more sensory regenerative effect as compared with 5-8j/cm2 dose and control group also did not show significant effect. The findings of the present study suggests nerve regeneration through nerve conduction velocity reports. Conclusion: It is evident from the results that an increase in nerve conduction velocity with selective dosages of laser proves that laser has neuroregenerative effects and by analyzing the results it can be concluded that low level laser of 3&4j/cm2 is found to be effective in regeneration of SNCV of experimentally induced diabetic neuropathy as compared with control group and with the dosage of higher energy with 5-8j/cm2.
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