MOLECULAR DOCKING ANALYSIS ON THE IDENTIFICATION THE ACTIVATION OF ENDOGENOUS BETA ENDORPHIN ON THE REGULATION OF NEURO INFLAMMATORY SIGNALLING RELEVANT TO INFLAMMATORY MEDIATED TUMOR
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 674-684
AbstractBACKGROUND: Beta-endorphin is an opioid neuropeptide which has an important role in paracrine communication of brain messages. Beta-endorphin is the link that is missed between the neuron and the wall of the arteriole, it is a fundamental neurotransmitter. When you exercise, a chemical is released by the body called beta-endorphins which interact with the receptors in your brain to reduce the perception of pain.
The molecular docking analysis is a bioinformatic study conducted in a private dental college. The endogenous substance Beta-endorphin which is secreted after exercise is used as a target protein.The interaction of beta-endorphin with the proteins relevant to inflammatory mediated tumor namely IL-6,TNF-alpha, MMP are included for docking analysis. The protein structure is retrieved using protein data bank, protein protein docking done using patch dock server followed by visualization of protein-protein interaction using pymol.
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