European Journal of Molecular & Clinical Medicine

Abstract

BACKGROUND: Beta-endorphin is an opioid neuropeptide which has an important role in paracrine communication of brain messages. Beta-endorphin is the link that is missed between the neuron and the wall of the arteriole, it is a fundamental neurotransmitter. When you exercise, a chemical is released by the body called beta-endorphins which interact with the receptors in your brain to reduce the perception of pain.
The molecular docking analysis is a bioinformatic study conducted in a private dental college. The endogenous substance Beta-endorphin which is secreted after exercise is used as a target protein.The interaction of beta-endorphin  with the proteins relevant to inflammatory mediated tumor namely IL-6,TNF-alpha, MMP are included for docking analysis. The protein structure is retrieved using protein data bank, protein protein docking  done using patch dock server followed by visualization of protein-protein interaction using pymol.