Formulation Development and Characterization Of Third Generation Cephalosporin Loaded Dry Injection and Dry Syrup: A Mixed Solvency Concept To Minimize Toxicity And Maximize Bioavailability
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 802-829
AbstractThe objective of present work was to explore the novel application of mixed solvency technique in the formulation of dry dosage forms of poorly soluble drug and to minimize the toxic effects of solubilizers by reducing the concentration of individual solubilizer (used for solubility enhancement).
In the present study, poorly water insoluble drug cefixime was selected. Cefixime was tried to solubilize by using solubilizers which were physiologically compatible in an attempt to prepare its parenteral formulations (dry injection for reconstitution of cefixime) as well as oral liquid formulation (dry syrup).
In the present work, the procured cefixime drug sample was characterized by various characterization tests. Open capillary method was used to determine the melting point and it was found to be 218-225º C. Spectrophotometric method was used to analyze the drug which showed its peak at 288 nm. Further characterization of drug was done by FTIR spectroscopy. The characterization report of the procured sample of drug was found to be in concordance with that reported in the literature and was thus used for further studies.
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