EVALUATION OF ENDOMETRIUM FOR CHRONIC ENDOMETRITIS BY USING IHC MARKER SYNDECAN-1 IN ABNORMAL UTERINE BLEEDING AT TERTIARY CARE CENTRE.
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 6388-6400
AbstractBackground: The endometrium which lines the uterine cavity is one of most dynamic tissues in the human body. The endometrial sampling is chosen to evaluate abnormal uterine bleeding. Chronic endometritis is considered as an infectious or a reactive process
Materials and Methods: It is a prospective study done for period of 2 years in Department of Pathology, Government Maternity Hospital, Hyderabad. Sample size was 50. All cases of Abnormal Uterine Bleeding in Reproductive age group were chosen and their endometrial curettage samples were processed, histopathological & immunohistochemical study was done. The results obtained were tabulated & assessed statistically.
Results: The present study showed that Staining with Immunohistochemical marker CD 138(Syndecan -1) could detect the presence of Plasma cells which were not seen in normal H & E staining. The 16 cases which showed the presence of plasma cells on H & E were positive for CD 138 and other 21 cases showed positivity for CD138 indicating presence of plasma cells in the endometrial stroma though they were not detected in routine H & E staining. The results obtained were statistically significant with ‘p’ value <0.05.
Conclusion: Syndecan-1(CD138) immunohistochemistry can improve the Chronic Endometritis diagnosis rate. Approximately half of the cases of chronic endometritis responded to an antibiotic regime; thus, this diagnosis is important and may potentially obviate the need for surgical intervention
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