European Journal of Molecular & Clinical Medicine

Abstract

Background: Cardiovascular disease (CVD’s) are the chief cause of mortality in country like India, were quarter of all mortality are due to CVD. Vitamin D inhibits inflammation through a variety of mechanisms. The aim of the study was to assess the influence of vitamin D level on the  lipid profile of patients of coronary artery disease.
Material & Method: The present hospital based observational study was conducted among the patients who are more than 18 yrs with signs, symptoms and investigation (ECG) of coronary artery disease admitted to the AVMC hospital. Patients with chronic kidney disease, patients with elevated CRP, fever, patients with cancer and on supplementation of Vitamin D3 were excluded from the study.  The lipid parameters and vitamin D3 were measured to assess the relation.
Results: In present study total of 160 patients included with mean age of patients was found to be 51.75±8.58yrs, 68.8% were male. Vitamin D deficiency was seen in 50%, insufficiency in 40.6% and sufficiency in 9.4% patients. We found a significant higher incidence of dyslipidemia among the patients with deficiency and insufficient vitamin D compared to sufficient vitamin D levels.(p<0.05) Also there is significant negative correlation of total cholesterol and LDL cholesterol with the vitamin D3 level and a significant positive correlation with the HDL cholesterol. (p<0.05)
Conclusion: There is higher incidence of presence of vitamin D deficiency and insufficiency among the patients with coronary artery disease in the present study