Role of Vitamin D in chronic low back pain in south Rajasthan: An Open-Label, Single-Arm Clinical Trial
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 7402-7411
Abstract
Objectives:The purpose of the study is to evaluate how vitamin D supplementation affects the severity of pain, functional impairment, and vitamin D levels in individuals with CLBP.Study design:An open-label, single-arm clinical trial
Setting: A tertiary care hospital's outpatient pain clinic
Methods:A total of 342 individuals were included in the study (CLBP for more than 3 months and plasma 25-hydroxyvitamin D3 levels of 30 ng/mL). For eight weeks, patients received 60,000 IU of oral vitamin D3 once a week as a supplement. At baseline, 2, 3, and 6 months after supplementation, VAS measurements of pain intensity and functional impairment were included as efficacy parameters. At baseline and eight weeks later, the levels of plasma 25 (OH) D3 were assessed.
Results:After taking vitamin D supplements, all 342 patients' serum vitamin D levels returned to normal. Of these, 84 patients had normal vitamin D levels and responded 69% to vitamin D therapy, while 258 patients had low vitamin D levels and responded 100% to vitamin D therapy for their LBP.
Conclusion:In addition to bringing levels back to normal, vitamin-D therapy in CLBP patients with vitamin-D deficiency may also reduce discomfort and enhance functional capacity. Controlled clinical trials in the future are necessary to verify the hypothesis.
- Article View: 3
- PDF Download: 11