European Journal of Molecular & Clinical Medicine

Abstract

Background- With sepsis as a major cause of concern in increasing ICU mortality, several prognostic scoring systems, including the Acute Physiology and Chronic Health Evaluation (APACHE)  or the Mortality Probability Models (MPM)have been used so far to assess the acute clinical condition of seriously ill patients with sepsis, to predict prognosis and to assist physicians clinical decision. 
Aim- To study the relationship of acute phase reactants level with severity of illness and mortality in patients with sepsis and its correlation with APACHE IV score
 
Study Design: Propective observational study.
Place and Duration of Study: This study was conducted at Department of General Medicine, Dr D Y Patil Medical College, Hospital and research centre, Pune from October 2020 to September 2022.
Methodology- This study conducted in a semi-urban teaching Hospital in Maharashtra, India. Study included patients admitted to ICCU of the study institute for sepsis (Sepsis is any suspected (or documented) infection and an acute increase in ≥2 sepsis-related organ failure assessment (SOFA) points.) and full filling the below mentioned inclusion and exclusion criteria.The collected data was analyzed with IBM, SPSS (IBM Corp., Statistics for Windows, version 24.0, Armonk, NY). Continuous variables were expressed as mean ± standard deviation (SD) and categorical variables were expressed as a percentage.
Results and Conclusion- Mean level of Acute phase reactants proteins like C reactive protein, ESR, lactate dehydrogenase level, D Dimer, Serum Procalcitonin, Serum lactate, Serum Ferritin, APACHE IV score was significantly higher in patients who died during the treatment as compared to patients who survived.